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On New Year's Eve, Dr. Steven Monks (Richard Johnson) calls for a quarantine in the British city of Bath after diagnosing a case of smallpox. His attention to the crisis is compromised by his struggling marriage to Julie (Claire Bloom), a former nurse whom he cheated on, who turns out to be infected herself. Just when the outbreak appears to be under control, it's discovered that the lone remaining case is that of Ruth Preston (Yolande Donlan), the woman with whom Monks had an affair.
